Choosing the right systemic fungicide can help protect trees and ornamental landscapes from a wide range of fungal diseases. This guide highlights five highly regarded products that offer systemic action, durability, and broad-spectrum control. Each option is suitable for lawns, landscapes, and tree-rich environments, helping you curb infections such as rusts, blights, powdery mildews, and root-related pathogens. Below you’ll find concise product overviews, key features, and a practical buying guide to aid comparisons and informed decisions.
Product Quick Reference
- Atticus Gravex 20 EW (16 oz) Fungicide — Myclobutanil systemic control
- Quest Reliant Systemic Fungicide 32oz/1 Quart — Broad-spectrum systemic protection
- Bonide Infuse Systemic Disease Control, 32 oz Ready-to-Spray — Wide disease coverage
- Reliant Systemic Fungicide (Agri-Fos/Garden Phos) 1 Gallon — Phytophthora and more
- Bonide Infuse Lawn & Landscape Systemic Disease Control, 7.5 lb Granules — Lawn and ornamentals
Note: The products listed here are evaluated for their systemic action, disease coverage, and suitability for trees in landscape settings. Always follow label directions for application timing, dilution, safety, and irrigation recommendations to protect beneficial organisms and local water quality.
Atticus Gravex 20 EW Fungicide

Atticus Gravex 20 EW delivers systemic control with 19.7% myclobutanil, the same active ingredient found in Eagle 20EW. This fungicide provides both curative and preventive action, making it a versatile choice for turf, landscapes, and greenhouse settings. It targets a broad spectrum of fungal threats, including common turf diseases like dollar spot, brown patch, and rust, while also offering protection for ornamentals.
Key features include lasting efficacy against a wide range of fungi and dual action that helps stop ongoing infections while preventing new ones. Gravex 20 EW is designed for use in lawns and landscapes where trees and ornamental plantings require dependable protection from fungal stress. For best results, follow label directions regarding mixing, timing, and reapplication intervals.
Quest Reliant Systemic Fungicide

Quest Reliant Systemic Fungicide (32 oz / 1 Quart) shares its formulation strength with widely used products like Agri-Fos and Garden Phos, offering robust control over Phytophthora, Pythium, mildews, cankers, and various leaf diseases. It also supports the plant’s natural defense mechanisms, helping complex plant defense systems resist pathogens. This makes it a suitable option for tree pockets and landscape plantings that face root and foliage diseases.
The product’s systemic action ensures internal distribution of the active ingredient, contributing to consistent protection across above- and below-ground plant tissues. Applicability spans trees, shrubs, and ornamentals, with considerations for irrigation and compatibility with other lawn and garden care regimes as indicated on the label.
Bonide Infuse Systemic Disease Control (32 oz Ready-to-Spray)

Bonide Infuse Systemic Disease Control provides broad-spectrum, systemic disease management for turf and ornamentals. This ready-to-spray formulation is designed to protect roses, flowers, lawns, trees, and shrubs from a broad array of diseases including rust, blight, powdery mildew, scab, and leaf spots. The systemic action supports internal disease suppression, making it a practical choice for property-wide disease management in landscapes with diverse plantings.
With a flexible application profile, Infuse supports lawn care programs and ornamental maintenance alike. Follow label directions for proper dilution, coverage, and re-entry intervals to maximize disease deterrence while preserving plant health and color.
Reliant Systemic Fungicide (Agri-Fos/Garden Phos) 1 Gallon

Reliant Systemic Fungicide aligns with the Agri-Fos/Garden Phos family and provides effective treatment for Phytophthora, Pythium, downy mildews, and a range of leaf spots and bacterial diseases. By activating plant defenses, it helps trees and ornamentals build resilience against invading pathogens. One-gallon sizing supports broader landscape programs or multiple-application planning across larger tree canopies and turf edges.
Bonide Infuse Lawn & Landscape Systemic Disease Control (7.5 lb Granules)

Infuse Lawn & Landscape Granules offer systemic disease control across lawns, trees, shrubs, and ornamentals. This product is designed for broad coverage, supporting turf rooting, color enhancement, and resilience against diseases such as dollar spot, rust, brown patch, powdery mildew, and leaf spots. The granule format can be convenient for larger landscapes and mixed plantings, especially when integrated into seasonal lawn care schedules.
Buying Guide: Key Considerations For Choosing A Systemic Fungicide For Trees
- Target diseases: Identify the most prevalent diseases in your region and on your tree species. Look for products with proven efficacy against those pathogens, including Phytophthora, Pythium, leaf spots, and rusts.
- Systemic action vs. contact action: Systemic fungicides move within the plant to provide internal protection. They are often paired with preventive plans and proper irrigation to ensure distribution. Consider your landscape’s watering practices and tree species when selecting a product.
- Active ingredient compatibility: Myclobutanil, fos-based formulations, and other actives have different spectra and safety profiles. Check compatibility with existing plant care products, soils, and irrigation water quality.
- Mode of application: Granules, ready-to-spray liquids, and concentrated formulations require different handling, mixing, and equipment. Ensure your existing spray equipment or spreaders are suitable for the product type.
- Coverage and sizing: For larger landscapes or estates, larger container sizes (gallons) can reduce reordering frequency. For smaller properties, ready-to-use sprays may be more convenient.
- Safety and environment: Follow label instructions for buffer zones near water sources, beneficial organisms, and non-target plants. Adhere to recommended re-entry intervals and personal protective equipment guidance.
- Integrated management: Combine systemic fungicides with cultural practices—proper pruning, improved air circulation, appropriate irrigation timing, and mowing height adjustments—to reduce disease pressure over time.
- Regulatory and local guidance: Some actives may have regional restrictions or advisories. Verify local agricultural extension recommendations before application.